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Search Results for " Na channels "

ターゲット

111

阻害剤

16

天然化合物

3

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T13177L Tocainide Sodium Channel
Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.
T5850 Benzamil Benzamil (hydrochloride) Na+/Ca2+ Exchanger , Sodium Channel
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.
T4490 PF-01247324 Sodium Channel
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
TQ0011 PF-06869206 Sodium Channel
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
T12786 RY785 Potassium Channel
RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.
T16514 PF 04531083 Others , Sodium Channel
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.
T15174 DSP-2230 Sodium Channel
DSP-2230 is a selective blocker of Nav1.7/Nav1.8.
TQ0014 GNE-131 Sodium Channel
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
T5324 BI 01383298 Sodium Channel
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
T37688 Cyfluthrin Reactive Oxygen Species , Sodium Channel
Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.
T23070 Nisoxetine hydrochloride Sodium Channel , Monoamine Transporter , Norepinephrine
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor
T19644 Benzonatate Sodium Channel
Benzonatate is an antagonist of sodium channel protein.
T8581 Flecainide hydrochloride Others
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.
T9683 VX-150 Sodium Channel
VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).
T0924 Benzocaine Others , MRP , Sodium Channel
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T1787 Levobupivacaine Sodium Channel
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...
T9685 DS-1971a Sodium Channel
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
T0364 Dibucaine Cinchocaine CaMK , Sodium Channel , AChR
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
T12181 NaV1.7 inhibitor-1 Sodium Channel
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
T7182 Metaflumizone BAS-320I Sodium Channel , Parasite
Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.
T3956 Sodium ionophore III ETH2120 Sodium Channel
Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.
T2049 GS967 GS458967 Sodium Channel
GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
T0939 Phenytoin Diphenylhydantoin,5,5-Diphenylhydantoin Virus Protease , Sodium Channel
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor...
T7547 Ralfinamide mesylate FCE-26742A (mesylate) Sodium Channel
Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.
T12421 PF-04885614 Sodium Channel
PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment.
T0275 Meticrane Fontiliz,Arresten Chloride channel , Sodium Channel
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
T7502L PF 05089771 PF-05089771,PF05089771 Sodium Channel
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.
T9461 AZ194 Sodium Channel
CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.
T6086 Clopamide Brinaldix,Adurix,Aquex Sodium Channel
Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.
T4539 Nicainoprol RU-42924 Sodium Channel
Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.
T12931 SLC13A5-IN-1 Stearoyl-CoA Desaturase (SCD)
T0916 Butamben Butyl 4-aminobenzoate Potassium Channel , Calcium Channel , Sodium Channel
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
T0030 Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl Sodium Channel
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol...
T6633 Ranolazine CVT 303,Ranexa,RS 43285-003 Calcium Channel , Sodium Channel
Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the...
T12608 QX-314 chloride Sodium Channel
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
T7502 PF 05089771 tosylate Sodium Channel
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...
T8711 PF-05186462 PF-05150122 Sodium Channel
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
T0680 Lamotrigine LTG,BW430C 5-HT Receptor , Sodium Channel , Autophagy
Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T0943 Carbamazepine NSC 169864 Mitophagy , Sodium Channel , Autophagy
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna...
T2024 A-803467 A 803467,A803467 Sodium Channel
A-803467 is a selective NaV1.8 channel blocker.
T15260 Evenamide NW-3509 Sodium Channel
Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
T7349 Ralfinamide Priralfinamide,FCE-26742A Sodium Channel
Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
T1409 Methocarbamol Lumirelax,Metocarbamol,AHR 85,Robaxin Sodium Channel , Carbonic Anhydrase
Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful musc...
T2342 Raxatrigine CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802 Sodium Channel
Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
T0806 Flunarizine dihydrochloride Flunarizine 2HCl,KW-3149,R14950 Calcium Channel , Dopamine Receptor , Sodium Channel
Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of mig...
T22675 Co 102862 V 102862 Others , Sodium Channel
Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.
T0946 Mepivacaine hydrochloride Mepivacaine HCl Sodium Channel
Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.
T0440 Oxcarbazepine GP 47680 Apoptosis , Sodium Channel
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.
T27205 DPI 201-106 DPI-201-106 Sodium Channel
DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents.
T7811 Pilsicainide HCl SUN 1165 Sodium Channel
Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker

Compounds

Tocainide
T13177L
Synonym:
Target: Sodium Channel
Benzamil
T5850
Synonym: Benzamil (hydrochloride)
Target: Na+/Ca2+ Exchanger, Sodium Channel
PF-01247324
T4490
Synonym:
Target: Sodium Channel
PF-06869206
TQ0011
Synonym:
Target: Sodium Channel
RY785
T12786
Synonym:
Target: Potassium Channel
PF 04531083
T16514
Synonym:
Target: Others, Sodium Channel
DSP-2230
T15174
Synonym:
Target: Sodium Channel
GNE-131
TQ0014
Synonym:
Target: Sodium Channel
BI 01383298
T5324
Synonym:
Target: Sodium Channel
Cyfluthrin
T37688
Synonym:
Target: Reactive Oxygen Species, Sodium Channel
Nisoxetine hydrochloride
T23070
Synonym:
Target: Sodium Channel, Monoamine Transporter, Norepinephrine
Benzonatate
T19644
Synonym:
Target: Sodium Channel
Flecainide hydrochloride
T8581
Synonym:
Target: Others
VX-150
T9683
Synonym:
Target: Sodium Channel
Benzocaine
T0924
Synonym:
Target: Others, MRP, Sodium Channel
Levobupivacaine
T1787
Synonym:
Target: Sodium Channel
DS-1971a
T9685
Synonym:
Target: Sodium Channel
Dibucaine
T0364
Synonym: Cinchocaine
Target: CaMK, Sodium Channel, AChR
NaV1.7 inhibitor-1
T12181
Synonym:
Target: Sodium Channel
Metaflumizone
T7182
Synonym: BAS-320I
Target: Sodium Channel, Parasite
Sodium ionophore III
T3956
Synonym: ETH2120
Target: Sodium Channel
GS967
T2049
Synonym: GS458967
Target: Sodium Channel
Phenytoin
T0939
Synonym: Diphenylhydantoin,5,5-Diphenylhydantoin
Target: Virus Protease, Sodium Channel
Ralfinamide mesylate
T7547
Synonym: FCE-26742A (mesylate)
Target: Sodium Channel
PF-04885614
T12421
Synonym:
Target: Sodium Channel
Meticrane
T0275
Synonym: Fontiliz,Arresten
Target: Chloride channel, Sodium Channel
PF 05089771
T7502L
Synonym: PF-05089771,PF05089771
Target: Sodium Channel
AZ194
T9461
Synonym:
Target: Sodium Channel
Clopamide
T6086
Synonym: Brinaldix,Adurix,Aquex
Target: Sodium Channel
Nicainoprol
T4539
Synonym: RU-42924
Target: Sodium Channel
SLC13A5-IN-1
T12931
Synonym:
Target: Stearoyl-CoA Desaturase (SCD)
Butamben
T0916
Synonym: Butyl 4-aminobenzoate
Target: Potassium Channel, Calcium Channel, Sodium Channel
Bupivacaine hydrochloride
T0030
Synonym: Vivacaine,Bupivacaine HCl
Target: Sodium Channel
Ranolazine
T6633
Synonym: CVT 303,Ranexa,RS 43285-003
Target: Calcium Channel, Sodium Channel
QX-314 chloride
T12608
Synonym:
Target: Sodium Channel
PF 05089771 tosylate
T7502
Synonym:
Target: Sodium Channel
PF-05186462
T8711
Synonym: PF-05150122
Target: Sodium Channel
Lamotrigine
T0680
Synonym: LTG,BW430C
Target: 5-HT Receptor, Sodium Channel, Autophagy
Carbamazepine
T0943
Synonym: NSC 169864
Target: Mitophagy, Sodium Channel, Autophagy
A-803467
T2024
Synonym: A 803467,A803467
Target: Sodium Channel
Evenamide
T15260
Synonym: NW-3509
Target: Sodium Channel
Ralfinamide
T7349
Synonym: Priralfinamide,FCE-26742A
Target: Sodium Channel
Methocarbamol
T1409
Synonym: Lumirelax,Metocarbamol,AHR 85,Robaxin
Target: Sodium Channel, Carbonic Anhydrase
Raxatrigine
T2342
Synonym: CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802
Target: Sodium Channel
Flunarizine dihydrochloride
T0806
Synonym: Flunarizine 2HCl,KW-3149,R14950
Target: Calcium Channel, Dopamine Receptor, Sodium Channel
Co 102862
T22675
Synonym: V 102862
Target: Others, Sodium Channel
Mepivacaine hydrochloride
T0946
Synonym: Mepivacaine HCl
Target: Sodium Channel
Oxcarbazepine
T0440
Synonym: GP 47680
Target: Apoptosis, Sodium Channel
DPI 201-106
T27205
Synonym: DPI-201-106
Target: Sodium Channel
Pilsicainide HCl
T7811
Synonym: SUN 1165
Target: Sodium Channel
1 2 3
カタログ番号 製品名 別名 ターゲット
T4S1876 3-Deoxyaconitine Sodium Channel
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele...
T8299 Dimethyl lithospermate B dmLSB Sodium Channel
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.
T3021 Bulleyaconitine A Bulleyaconi cine A Sodium Channel
Bulleyaconitine A (Bulleyaconi cine A), an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.
T4590 (+)-Kavain Kavain,L-KAWAIN,(R)-KAWAIN Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
T4550 Ajmaline Cardiorythmine,Raugalline,Tachmalin,(+)-Ajmaline Sodium Channel
Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and...
T7056 Dronedarone SR 33589 P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T0167 Vinpocetine RGH-4405,Ethyl apovincaminate IκB/IKK , NF-κB , Sodium Channel , PDE
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
TN6713 6-Benzoylheteratisine Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth Sodium Channel
6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes
T3524 Halofuginone hydrobromide Tempostatin,RU-19110 (hydrobromide),Stenorol Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T2173 Veratridine Sodium Channel
Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
T3402 20(S)-Ginsenoside Rg3 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c...
T4S1869 12-Epinapelline Others
12- Epinapelline is a diterpene alkaloid which displays anaesthetic activity as toxic neurological agents. Similar to aconitine, its suggested that modulation of voltage gated Na+ channels are responsible for these obser...
TN2347 Methylsticin Methysticin Others
Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neu...
T10609 Brevetoxin-3 PbTx-3 Others
T82764 Cd1a β-TRTX-cd1a,β-Theraphotoxin-cd1a
Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) as well as mouse sodium ion channels (Na v 1.7). This compound...

天然物製品

3-Deoxyaconitine
T4S1876
Synonym:
Target: Sodium Channel
Dimethyl lithospermate B
T8299
Synonym: dmLSB
Target: Sodium Channel
Bulleyaconitine A
T3021
Synonym: Bulleyaconi cine A
Target: Sodium Channel
(+)-Kavain
T4590
Synonym: Kavain,L-KAWAIN,(R)-KAWAIN
Target: Calcium Channel, GABA Receptor, Sodium Channel, Monoamine Transporter
Ajmaline
T4550
Synonym: Cardiorythmine,Raugalline,Tachmalin,(+)-Ajmaline
Target: Sodium Channel
Dronedarone
T7056
Synonym: SR 33589
Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy
Vinpocetine
T0167
Synonym: RGH-4405,Ethyl apovincaminate
Target: IκB/IKK, NF-κB, Sodium Channel, PDE
Halofuginone
T6856
Synonym: Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
6-Benzoylheteratisine
TN6713
Synonym: Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth
Target: Sodium Channel
Halofuginone hydrobromide
T3524
Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Veratridine
T2173
Synonym:
Target: Sodium Channel
20(S)-Ginsenoside Rg3
T3402
Synonym: 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3
Target: EGFR, Beta Amyloid, Potassium Channel, NF-κB, COX, Sodium Channel, Endogenous Metabolite
12-Epinapelline
T4S1869
Synonym:
Target: Others
Methylsticin
TN2347
Synonym: Methysticin
Target: Others
Brevetoxin-3
T10609
Synonym: PbTx-3
Target: Others
Cd1a
T82764
Synonym: β-TRTX-cd1a,β-Theraphotoxin-cd1a
Target:

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-00720 Contactin 1 Protein, Human, Recombinant (His) Human HEK293
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3...
TMPH-01027 CAMK2D Protein, Human, Recombinant (His) Human E. coli
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in C...
TMPY-03676 Contactin 1 Protein, Mouse, Recombinant (His) Mouse HEK293
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3...
カタログ番号 製品名
L7400 Sodium Channel Blocker Library

128 compounds
A unique collection of 128 sodium channel blockers and agonists for high throughput and high content screening;