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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T13177L | Tocainide | Sodium Channel | |
Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus. | |||
T5850 | Benzamil | Benzamil (hydrochloride) | Na+/Ca2+ Exchanger , Sodium Channel |
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. | |||
T4490 | PF-01247324 | Sodium Channel | |
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM). | |||
TQ0011 | PF-06869206 | Sodium Channel | |
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM). | |||
T12786 | RY785 | Potassium Channel | |
RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies. | |||
T16514 | PF 04531083 | Others , Sodium Channel | |
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies. | |||
T15174 | DSP-2230 | Sodium Channel | |
DSP-2230 is a selective blocker of Nav1.7/Nav1.8. | |||
TQ0014 | GNE-131 | Sodium Channel | |
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). | |||
T5324 | BI 01383298 | Sodium Channel | |
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). | |||
T37688 | Cyfluthrin | Reactive Oxygen Species , Sodium Channel | |
Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests. | |||
T23070 | Nisoxetine hydrochloride | Sodium Channel , Monoamine Transporter , Norepinephrine | |
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor | |||
T19644 | Benzonatate | Sodium Channel | |
Benzonatate is an antagonist of sodium channel protein. | |||
T8581 | Flecainide hydrochloride | Others | |
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. | |||
T9683 | VX-150 | Sodium Channel | |
VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold). | |||
T0924 | Benzocaine | Others , MRP , Sodium Channel | |
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. | |||
T1787 | Levobupivacaine | Sodium Channel | |
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ... | |||
T9685 | DS-1971a | Sodium Channel | |
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. | |||
T0364 | Dibucaine | Cinchocaine | CaMK , Sodium Channel , AChR |
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia. | |||
T12181 | NaV1.7 inhibitor-1 | Sodium Channel | |
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7). | |||
T7182 | Metaflumizone | BAS-320I | Sodium Channel , Parasite |
Metaflumizone (BAS-320I) is a sodium channel blocker insecticide. | |||
T3956 | Sodium ionophore III | ETH2120 | Sodium Channel |
Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood. | |||
T2049 | GS967 | GS458967 | Sodium Channel |
GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ). | |||
T0939 | Phenytoin | Diphenylhydantoin,5,5-Diphenylhydantoin | Virus Protease , Sodium Channel |
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor... | |||
T7547 | Ralfinamide mesylate | FCE-26742A (mesylate) | Sodium Channel |
Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker. | |||
T12421 | PF-04885614 | Sodium Channel | |
PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment. | |||
T0275 | Meticrane | Fontiliz,Arresten | Chloride channel , Sodium Channel |
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity. | |||
T7502L | PF 05089771 | PF-05089771,PF05089771 | Sodium Channel |
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent. | |||
T9461 | AZ194 | Sodium Channel | |
CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor. | |||
T6086 | Clopamide | Brinaldix,Adurix,Aquex | Sodium Channel |
Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity. | |||
T4539 | Nicainoprol | RU-42924 | Sodium Channel |
Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent. | |||
T12931 | SLC13A5-IN-1 | Stearoyl-CoA Desaturase (SCD) | |
T0916 | Butamben | Butyl 4-aminobenzoate | Potassium Channel , Calcium Channel , Sodium Channel |
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain. | |||
T0030 | Bupivacaine hydrochloride | Vivacaine,Bupivacaine HCl | Sodium Channel |
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol... | |||
T6633 | Ranolazine | CVT 303,Ranexa,RS 43285-003 | Calcium Channel , Sodium Channel |
Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the... | |||
T12608 | QX-314 chloride | Sodium Channel | |
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel. | |||
T7502 | PF 05089771 tosylate | Sodium Channel | |
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8... | |||
T8711 | PF-05186462 | PF-05150122 | Sodium Channel |
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5. | |||
T0680 | Lamotrigine | LTG,BW430C | 5-HT Receptor , Sodium Channel , Autophagy |
Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorganized Electrical Activity. | |||
T0943 | Carbamazepine | NSC 169864 | Mitophagy , Sodium Channel , Autophagy |
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna... | |||
T2024 | A-803467 | A 803467,A803467 | Sodium Channel |
A-803467 is a selective NaV1.8 channel blocker. | |||
T15260 | Evenamide | NW-3509 | Sodium Channel |
Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness. | |||
T7349 | Ralfinamide | Priralfinamide,FCE-26742A | Sodium Channel |
Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions. | |||
T1409 | Methocarbamol | Lumirelax,Metocarbamol,AHR 85,Robaxin | Sodium Channel , Carbonic Anhydrase |
Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful musc... | |||
T2342 | Raxatrigine | CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802 | Sodium Channel |
Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. | |||
T0806 | Flunarizine dihydrochloride | Flunarizine 2HCl,KW-3149,R14950 | Calcium Channel , Dopamine Receptor , Sodium Channel |
Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of mig... | |||
T22675 | Co 102862 | V 102862 | Others , Sodium Channel |
Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies. | |||
T0946 | Mepivacaine hydrochloride | Mepivacaine HCl | Sodium Channel |
Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. | |||
T0440 | Oxcarbazepine | GP 47680 | Apoptosis , Sodium Channel |
Oxcarbazepine (GP 47680) is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity. | |||
T27205 | DPI 201-106 | DPI-201-106 | Sodium Channel |
DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents. | |||
T7811 | Pilsicainide HCl | SUN 1165 | Sodium Channel |
Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T4S1876 | 3-Deoxyaconitine | Sodium Channel | |
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele... | |||
T8299 | Dimethyl lithospermate B | dmLSB | Sodium Channel |
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. | |||
T3021 | Bulleyaconitine A | Bulleyaconi cine A | Sodium Channel |
Bulleyaconitine A (Bulleyaconi cine A), an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels. | |||
T4590 | (+)-Kavain | Kavain,L-KAWAIN,(R)-KAWAIN | Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter |
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. | |||
T4550 | Ajmaline | Cardiorythmine,Raugalline,Tachmalin,(+)-Ajmaline | Sodium Channel |
Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and... | |||
T7056 | Dronedarone | SR 33589 | P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy |
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. | |||
T0167 | Vinpocetine | RGH-4405,Ethyl apovincaminate | IκB/IKK , NF-κB , Sodium Channel , PDE |
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). | |||
T6856 | Halofuginone | Tempostatin,empostatin,RU-19110 | Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. | |||
TN6713 | 6-Benzoylheteratisine | Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth | Sodium Channel |
6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
T2173 | Veratridine | Sodium Channel | |
Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal. | |||
T3402 | 20(S)-Ginsenoside Rg3 | 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 | EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite |
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c... | |||
T4S1869 | 12-Epinapelline | Others | |
12- Epinapelline is a diterpene alkaloid which displays anaesthetic activity as toxic neurological agents. Similar to aconitine, its suggested that modulation of voltage gated Na+ channels are responsible for these obser... | |||
TN2347 | Methylsticin | Methysticin | Others |
Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neu... | |||
T10609 | Brevetoxin-3 | PbTx-3 | Others |
T82764 | Cd1a | β-TRTX-cd1a,β-Theraphotoxin-cd1a | |
Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) as well as mouse sodium ion channels (Na v 1.7). This compound... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-00720 | Contactin 1 Protein, Human, Recombinant (His) | Human | HEK293 |
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3... | |||
TMPH-01027 | CAMK2D Protein, Human, Recombinant (His) | Human | E. coli |
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in C... | |||
TMPY-03676 | Contactin 1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3... |
カタログ番号 | 製品名 | ||
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L7400 | Sodium Channel Blocker Library | 128 compounds | |
A unique collection of 128 sodium channel blockers and agonists for high throughput and high content screening; |